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基质金属蛋白酶MMP-9、TIMP-1及VEGF的表达情况与非小细胞肺癌组织侵袭的相关性
梁乃超1,2
1.(1)承德市丰宁满族自治县医院外一科,河北 承德 068350;2.2)上海交通大学医学院附属第九人民医院心胸外科,上海 201999)
摘要:
[摘要]目的 探讨基质金属蛋白酶-9(Matrix metalloproteinase-9,MMP-9)、基质金属蛋白酶抑制剂-1(Matrix metalloproteinase inhibitor-1,TIMP-1)及血管内皮生长因子(vascular endothelial growth factor,VEGF)的表达水平与非小细胞肺癌组织侵袭的相关性.方法 采用回顾性方法分析,选取自2014年1月至2015年1月丰宁满族自治县医院收治的68例非小细胞肺癌患者的手术标本作为研究对象,采用免疫组化法分析非细胞肺癌组织与癌旁正常组织中MMP-9、TIMP-1、VEGF的表达水平.结果 肺癌组织中的MMP-9(75.00%)、TIMP-1(70.59%)、VEGF(66.18%)的阳性率均高于癌旁正常组织(16.18%、19.12%、13.24%),均具有统计学意义(P<0.05);腺癌组织中的MMP-9(60.87%)、TIMP-1(65.22%)、VEGF(76.09%)阳性率与鳞癌(59.09%、54.55%、63.64%)相比,均差异无统计学意义(P>0.05);有淋巴结转移患者的MMP-9、TIMP-1、VEGF的阳性率均高于无淋巴结转移者(P<0.05);MMP-9、TIMP-1、VEGF的阳性率随着非小细胞肺癌组织分期的增加而上升,呈现正相关(P<0.05).结论 MMP-9、TIMP-1、VEGF表达水平可预测非小细胞肺癌组织侵袭、转移情况,且3种物质均在不同程度上促进非细胞肺癌疾病的发展及恶化.
关键词:  [关键词]非小细胞肺癌组织  MMP-9  TIMP-1  VEGF  表达水平  侵袭
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基金项目:[基金项目]国家自然科学基金资助项目(81371350)
Correlation between Expression of MMP-9, TIMP-1 and VEGF and the Invasion of Non Small Cell Lung Cancer
LIANG Nai-chao1,2
1.(1)Dept. of Surgery,Fengning Manchu Autonomous County Hospital,Chengde Hebei,Chengde Hebei 068350;2)Dept. of Thoracic Surgery,The Ninth people’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 201999,China)
Abstract:
[Abstract]Objective To investigate the relationship between metalloproteinase-9 -9 (Matrix), inhibitor-1 -1(MMP-9),metalloproteinase TIMP-1 factor(Matrix) and endothelial growth (VEGF), and to investigate the correlation between the expression of(matrix) and vascular endothelial growth factor (endothelial)and vascular endothelial growth factor(vascular). Methods Sixty-eight cases of non small cell lung cancer patients treated in fengning manchu autonomous county hospital from January to January 2014 were analyzed retrospectively, and the expression level of TIMP-1, VEGF and MMP-9 were analyzed by immunohistochemical method. Results The positive rates of MMP-9(75%),TIMP-1(19.12%)and VEGF (13.24%)were significantly higher than those in normal tissues(P<0.05),MMP-9 (60.87%),VEGF (54.55%),TIMP-1 (65.22%) and VEGF (76.09%, 59.09%,63.64%). The positive rates of TIMP-1,VEGF and MMP-9 were higher than those without lymph node metastasis(P<0.05). Conclusion MMP-9,TIMP-1 and VEGF expression levels can predict the invasion and metastasis of non small cell lung cancer,and the three kinds of substances can promote the development and progression of lung cancer in different degrees.
Key words:  [Key words]Non small cell lung cancer tissue  MMP-9  TIMP-1  VEGF  Expression level  Invasion