| 摘要: |
| ［摘要］目的 探讨TNF-α基因启动子SNP-C/T（rs1799724）和ALCAM基因3'UTR区SNP-A/G（rs11559013）位点与HCV慢性感染的相关性．方法 入选云南地区汉族人群HCV慢性感染患者434例，健康体检人群444例．采用TaqMan探针基因分型方法对TNF-α基因启动子SNP-C/T（rs1799724）和ALCAM基因3'UTR区SNP-A/G（rs11559013）的2个位点进行基因分型，评估上述2个SNPs与HCV慢性感染的相关性．结果 在病例组和对照组中，TNF-α基因启动子SNP-C/T（rs1799724）和ALCAM基因3'UTR区SNP-A/G（rs11559013）基因型频率和等位基因频率差异没有统计学意义（P＞0.05）．结论 在云南汉族群体中，TNF-α基因启动子SNP-C/T（rs1799724）和ALCAM基因3'UTR区SNP-A/G（rs11559013）与HCV慢性感染没有相关性． |
| 关键词: ［关键词］HCV 慢性感染 单核苷酸多态性 TNF-α ALCAM |
| DOI： |
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| 基金项目:［基金项目］国家自然科学基金资助项目（81160197）；吴阶平医学基金资助项目（320.6750.13395） |
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| Association Study of TNF-α and ALCAM Polymorphisms with Chronic HCV Infection in Yunnan Han Population |
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LIU Cheng-xiu1,2
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1.（1）Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College， Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease，Kunming 650118;2）The First People’s Hospital in Yunnan Province and The Affiliated Hospital of Kunming Science and Technology University，Kunming Yunnan 650032，China）
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| Abstract: |
| ［Abstract］Objective To discuss the association of allele polymorphisms SNP-rs1799724 （C＞T） in the TNF-α and SNP-rs11559013（G＞A） in the ALCAM with HCV chronic infection in Han population in Yunnan province. Methods 434 HCV chronic infectious patients and 444 healthy individuals of Han Chinese population in Yunnan province were recruited. Two single nucleotide polymorphisms （SNPs） in the SNP-rs1799724（C＞T） of TNF-α gene and SNP-rs11559013（G＞A）of ALCAM gene were determined by real-time TaqMan polymerase chain reaction. We evaluated the associations of the two SNPs with HCV chronic infection. Results The distributions of allele and genotype of SNP-rs1799724（C＞T） in the TNF-α and SNP-rs11559013（G＞A）in the ALCAM between hepatitis C virus （HCV） chronic infectious patients and the healthy controls were not statistically significant （P > 0.05）. Conclusion SNP-rs1799724（C＞T） in the TNF-α and SNP-rs11559013（G＞A） in the ALCAM have no association with HCV chronic infection in the Han population in Yunnan province. |
| Key words: ［Key words］HCV Chronic infection SNPs TNF-α ALCAM |