| 滇丹参、甘西鼠尾、褐毛甘西鼠尾对离体豚鼠心脏的影响 |
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| 引用本文： | 闫彩珍,李惠兰,张荣平,胡建林.滇丹参、甘西鼠尾、褐毛甘西鼠尾对离体豚鼠心脏的影响[J].昆明医学院学报,2002,23(1):14-17. |
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| 作者姓名： | 闫彩珍 李惠兰 张荣平 胡建林 |
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| 作者单位： | 1. 昆明医学院药理教研室
2. 昆明医学院药学系,昆明,650031 |
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| 基金项目： | 云南省科委应用基础研究基金资助项目 (No :98C0 6 7M) |
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| 摘 要： | 采用Langendorff离体豚鼠心脏灌流法，观察滇产3种唇形科鼠尾属药物扩张冠脉作用并与标准丹参进行比较，结果发现：4种药物在高剂量可明显增加正常离体豚鼠心脏的冠脉流量、降低心肌收缩力、减慢心率（P＜0．05，P＜0．01），甘西鼠改进低剂量即能增加冠脉流量（P＜0．05），4种药物高、低剂量均能够对抗垂体后叶素致冠脉流量的减少和心肌收缩力的减弱（P＜0．05，P＜0．01）。结果表明，滇产3种丹参均能够增加正常离体豚鼠冠脉流量，对抗垂体后叶素致冠脉流量的减少。
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| 关 键 词： | 滇丹参 甘西鼠尾 褐毛甘西鼠尾 豚鼠 冠脉流量 收缩力 离体心脏 中药 影响 |
| 文章编号： | 1003-4706(2002)01-0014-04 |
| 修稿时间： | 2001年10月20 |
Effects of S. Yunnanensis C.H.Wright, S. Przewalskii and S. Przewalskii Maxim Var Maxim Mandarinorum Stib on Isolated Langendorff Perfusion Guinea Pig Heart |
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| YAN Cai-zheng ,LI Hui-lan ,ZHANG Rong-ping ,HU Jian-lin.Effects of S. Yunnanensis C.H.Wright, S. Przewalskii and S. Przewalskii Maxim Var Maxim Mandarinorum Stib on Isolated Langendorff Perfusion Guinea Pig Heart[J].Journal of Kunming Medical College,2002,23(1):14-17. |
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| Authors: | YAN Cai-zheng LI Hui-lan ZHANG Rong-ping HU Jian-lin |
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| Affiliation: | YAN Cai-zheng 1),LI Hui-lan 1),ZHANG Rong-ping 2),HU Jian-lin 2) |
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| Abstract: | The aim of this study was to investigate the effects of S.Yunnanensis C.H.Wright, S.Przewalskii Maxim and S.Przewalski Maxim var mandarinorum Stib on coronary flow, myocardial contractility and heart rate in isolated langendorff perfusion guinea pig heart. The results are as follows: the three drugs, at dose of 1 5, 3 0?mg/mL markedly increased coronary flow in normal isolated perfusion guinea pig heart, decreased myocardial contractility and heart rate(P<0 05, P<0 01), and Przewalskii Maxim was more efficient than Slavia mitiorrhiza Bunge in small dose(P<0 05). In the treated groups, coronary flow markedly increased in normal isolated perfusion guinea pig heart and significantly antagonized the reduction of myocardial contractility and coronary flow resulting from Posteriro Pituitary in a dose-dependent manner(P<0 05, P<0 01) , and the 4 drugs showed similar efficiency. |
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| Keywords: | S Yunnanensis C H Wright S Przewalskii Maxim S Przewalskii Maxim var mandarinorum Stib Guinea pig Coronary blood flow Myocardial contractility |
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