| 开胸结扎兔冠状动脉致急性心肌梗塞实验模型的研究 |
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| 引用本文： | 孙林,李易,光雪峰,徐章,曾河.开胸结扎兔冠状动脉致急性心肌梗塞实验模型的研究[J].昆明医学院学报,2001,22(1):39-41. |
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| 作者姓名： | 孙林 李易 光雪峰 徐章 曾河 |
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| 作者单位： | 1. 昆明医学院第二附属医院心内科
2. 昆明医学院第二附属医院动物实验室, |
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| 基金项目： | 云南省自然科学基金!资助项目 (1999C 0 0 2 9G) |
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| 摘 要： | 为了建立急性心肌梗塞动物模型，20只实验兔于无菌条件下开胸结扎冠状动脉左前降支（LAD），并观察心电图（ECG）、血清心肌酶及其同工酶的变化。结果：术前描记心电图均正常；结扎LAD即刻有7只，30min后有9只兔可见ST段抬,心电图呈现动态变化；结扎LAD后2h有2只兔心肌梗塞图形不典型，2只术中死亡；术后4周18只兔心电图描记均见胸导联有病理性Q波，结扎LAD后24h，血清心肌酶AST，LDH，LDH－1，CK，CK-MB明显升高，与术前比较（除LDH外）均有显著差异（P＜0.01），结果表明：该法操作简单，重复性好，形成梗塞可靠，术后可长期饲养，为临床冠心病的实验研究提供了一个有价值的动物模型。
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| 关 键 词： | 急性心肌梗塞 冠状动脉 疾病模型 动物模型 开胸结扎术小 |
| 文章编号： | 1003-4706(2001)01-0039-03 |
| 修稿时间： | 2000年10月20 |
Experimental Model of Acute Myocardial Infarction Induced by Ligation of Coronary Artery in Rabbits |
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| SUN Lin,LI Yi,GUANG Xue-feng,Xu Zhang,Zeng He.Experimental Model of Acute Myocardial Infarction Induced by Ligation of Coronary Artery in Rabbits[J].Journal of Kunming Medical College,2001,22(1):39-41. |
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| Authors: | SUN Lin LI Yi GUANG Xue-feng Xu Zhang Zeng He |
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| Affiliation: | SUN Lin 1),LI Yi 1),ZENG He 2),GUANG Xue-feng 1),XU Zhang 1) |
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| Abstract: | Objective an experimental animal model of acute myocardial infarction (ANI) was established by opening chest and ligation of the left anterior descending (LAD) coronary artery. Methods a total of 20 rabbits were opened chest and ligated LAD under sterilization. Electrocardiogram (ECG) and myocardial-enzymes in blood serum were investigated. Results ECG of all rabbits showed normal before operation. Irmediately after and 1/2 hour after ligation, ST-segment elevated and ECG showed ambulatory changes for 7 and 9 rabbits respectively. Two hours after LAD ligation, the change of ECG for 2 rabbits was not typical and 2 of them died during experiment. Four weeks after operation, ECG of 18 rabbits showed the chest leads had pathologic Q waves. Twenty-four hours after LAD ligation, AST, LDH, LDH-1, CK and CK-MB in blood serum were significantly increased. There was significant difference compared with before operation (except LDH) (P<0 0l). Conclusions:The method was simple and well repeated. The formation of myocardial infarction was reliable and rabbits were maintained for a long time after operation. It provides a valuable animal model for the experiment study of coronary heart disease. |
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| Keywords: | Acute myocardial infarction Coronary artery Experimental model Animal |
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