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阿茨海默病的 Hcy、 CRP变化与精神行为相关性临床观察
黄 微
( 云南省第三人民医院,云南 昆明 650011)
摘要:
[摘要]目的 探讨同型半胱氨酸水平(Hcy)和超敏C 反应蛋白(hs-CRP)与阿尔茨海默病(AD)病临床表现精神行为的关系.方法 选择云南省第三人民医院2014 年1 月至2016 年1 月住院的AD 患者20例,以酶法检测AD患者治疗前后血浆Hcy 与hs-CRP 水平,阿尔茨海默病病理行为(BEHAVE-AD) 评定量表评估患者治疗效果,分析Hcy 与hs-CRP水平与AD患者精神行为症状的相关性.结果 AD 患者的精神行为评分与血浆Hcy、hs-CRP浓度治疗前后水平对比均存在差异(P<0.01).结论 Hcy,CRP浓度与AD患者精神行为有相关性.
关键词:  [关键词]阿尔茨海默病  同型半胱氨酸  C-反应蛋白  精神行为表现  
DOI:
分类号:
基金项目:[基金项目]云南省科技厅应用基础研究基金资助项目(2013FB043),云南省教育厅科研基金资助项目(2012Z093,2015Z150)
Study on the Relationship between Homocysteine(Hcy)and C Reactive Protein(CRP)Levels and Mental Behaviors of Alzheimer’s Disease
HUANG Wei
(The Third People’s Hospital of Yunnan Province,Kunming Yunnan 650011,China)
Abstract:
[Abstract]Objective To study the relationship between homocysteine (Hcy) and hypersensitive c-reactive protein(hs - CRP)level and mental behaviors of Alzheimer's disease (AD) . Methods During the period from 2014 January to 2016 January,20 subjects were selected from inpatients of the third hospital of yunnan porvince,before and after treatment, the plasma levels of Hcy and hs-CRP in patients with AD were tested by enzymatic methods. The pathological behavior rating scale (concerns - AD) was used to estimate the treatment effect. Results There were significant differences in the mental behavior score and Hcy and CRP levels between the before and after the treatment in AD patients(P<0.01).Conclusion Plasma levels of Hcy and CRP have correlation with mental behaviors of patients with AD.
Key words:  [Key words]Alzheimer's disease  Homocysteine  C - reactive protein  Mental behavior