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西乐葆对骨折延迟愈合患者血液流变学和炎症因子水平的影响
李 飞1,2
1.(1)府谷县人民医院骨科,陕西 府谷 719400;2.2)云南省中医医院放射科,云南 昆明 650021)
摘要:
[摘要]目的 研究西乐葆对骨折延迟愈合患者血液流变学和血清细胞间黏附因子-1(serum intercelluar adhesion molecule-1,sICAM-1)、血管细胞黏附因子(serum vascular cell adhesion molecule-1, sVCAM-1)、肿瘤坏死因子-α(tumour necrosis factor-α, TNF-α)以及白介素-6(interleukin-6, IL-6)水平的影响.方法 将府谷县人民医院收治的201例骨折延迟愈合患者随机分为观察组(n=101)和对照组(n=100).其中对照组患者行常规手术内固定进行治疗,观察组加服西乐葆进行治疗.比较2组患者的临床疗效以及治疗前后血液流变学指标及血清sICAM-1、sVCAM-1、TNF-α以及IL-6水平的变化.结果 观察组治疗总有效率为94.1%,显著高于对照组70.0%,差异具有统计学意义(P<0.01);2组患者在治疗前血液流变学指标和血清sICAM-1、sVCAM-1、TNF-α、IL-6水平比较,差异均无统计学意义(P>0.05).治疗后2组患者各血液流变学指标及血清sICAM-1、sVCAM-1、TNF-α以及IL-6水平均有明显下降,且观察组下降程度优于对照组,差异均具有统计学意义(P<0.05).结论 西乐葆能够明显改善骨折延迟愈合患者血液流变学指标,降低血清sICAM-1、sVCAM-1、TNF-α以及IL-6水平,提高治疗效果,值得临床推广应用.
关键词:  [关键词]西乐葆  骨折延迟愈合  血液流变学  炎症反应
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基金项目:[基金项目]云南省卫生科技计划项目(2014NS336)
Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing
LI Fei1,2
1.(1)Dept. of Orthopaedics,Fugu County People’s Hospital,Fugu Shaanxi 719400;2)Dept. of Radiology,Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming Yunnan 650022,China)
Abstract:
[Abstract]Objective To investigate the effect of Celebrex on hemorheology and levels of serum intercelluar adhesion molecule-1(sICAM-1),serum vascular cell adhesion molecule-1(sVCAM-1),tumour necrosis factor-α(TNF-α),interleukin-6 (IL-6) in patients with delayed fracture healing. Methods 201 patients with delayed fracture healing in our hospital were randomly divided into observation group(n=101)and control group (n=100). The patients in control group received conventional surgical internal fixation,while patients in observation group received conventional surgical internal fixation combined with Celebrex. The clinical efficacy was observed, while the changes of hemorheology and levels of sICAM-1, sVCAM-1, TNF-α, IL-6 were compared between two groups before and after treatment.Results The effective rate of observation group was 94.1%, which was significant higher than that of control group 70.0%(P<0.01). There were no significantly differences between two groups in the indexes of hemorheology and levels of sICAM-1,sVCAM-1,TNF-α,IL-6 before treatment(P>0.05). The indexes of hemorheology and levels of sICAM-1,sVCAM-1,TNF-α,IL-6 were significantly reduced after treatment, while the decreased degrees of observation group were better than those of control group,with statistically significant difference(P<0.05). Conclusions Celebrex can improve the indexes of hemorheology,reduce the levels of sICAM-1,sVCAM-1, TNF-α, IL-6 and improve the clinical effect in treatment of delayed fracture healing. It is worth of popularization and application.
Key words:  [Key words]Celebrex  Delayed fracture healing  Hemorheology  Inflammatory factors