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脂肪因子Vaspin、Apelin及瘦素与多囊卵巢综合征的相关性
蒋婷婷
(昆明医科大学第二附属医院,云南 昆明 650101)
摘要:
[摘要]目的 探讨脂肪因子Vaspin、Apelin及瘦素(Leptin)与多囊卵巢综合征(polycystic ovary syndrome,PCOS)相关性.方法 测定40例PCOS患者及30例对照组的血清Vaspin、Apelin及瘦素水平,并将PCOS组按WHO肥胖标准分为体重正常组、超重组及肥胖组,分析血清Vaspin、Apelin及瘦素水平在PCOS与对照组中的差异和在不同体重指数(Body mass index,BMI)PCOS患者中的差异,探讨脂肪因子Vaspin、Apelin及瘦素在PCOS发病机制中的作用.结果 PCOS患者脂肪因子Vaspin、Apelin、瘦素、胰岛素抵抗指数(Homeostasis model assessment for Insulin resistence index,HOMA-IR)、空腹胰岛素(Lnsulin,INS)及血糖、血脂高于对照组,随着BMI的增加而升高,且三种脂肪因子与PCOS患者HOMA-IR正相关,差异有统计学意义(P<0.05).结论 脂肪因子vaspin、apelin及瘦素可能参与了PCOS的发生.
关键词:  [关键词]多囊卵巢综合征  脂肪因子  胰岛素抵抗  肥胖
DOI:
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基金项目:[基金项目]云南省科技厅-昆明医科大学联合专项基金资助项目(2013FZ272)
The Relationship Between Polycystic Ovary Syndrome and Vaspin,Apelin and Leptin
JIANG Ting-ting
(The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)
Abstract:
[Abstract]Objective To investigate the relationship between vaspin, Apelin, leptin and polycystic ovary syndrome. Methods We determined the serum vaspin,Apelin and leptin levels of 40 cases of PCOS patients and 30 cases of control group,and divided the PCOS group into three subgroups(normal weight, overweight and obesity)according to WHO criteria for obesity. Then we compared the serum vaspin,Apelin and leptin levels in PCOS and control group,and the differences in body weight index(body mass index,BMI) in women with polycystic ovary syndrome,and analyzed roles of adipokine vaspin,Apelin and leptin in the pathogenesis of PCOS. Results In PCOS patients adipokine vaspin,Apelin,leptin,insulin resistance index(Homeostasis model assessment for insulin index in resistence,HOMA-IR),fasting insulin (INS) and blood glucose,blood lipid were higher than those of the control group and increased with the increase of body mass index(BMI),and three kinds of adipokines and PCOS patients with HOMA-IR were positively correlated, there were statistically significant differences (P < 0.05). Conclusion The results of vaspin, Apelin and leptin may be involved in the occurrence of PCOS.
Key words:  [Key words]Polycystic Ovary Syndrome  Fat factors  Insulin resistance  Obesity