| 摘要: |
| ［摘要］目的 分析霍奇金淋巴瘤(HL)的临床病理特点．方法 回顾性分析昆明医科大学第三附属医院2003年1月1日至2012年12月31日收治的HL的临床病理资料，统计所有HL患者的性别、年龄、病理类型、首发症状，起病部位、临床分期、结外侵犯范围、ECOG评分、治疗情况．结果 143例霍奇金淋巴瘤男女比例为2.5:1，中位年龄37岁（11～73岁），以混合细胞型（34.3%）及结节硬化型（28.0%）最常见．淋巴结起病者占97.2%，最常见为颈部及锁骨上淋巴结（74.1%），结外起病者占2.1%．临床分期以Ⅰ/Ⅱ期最多见，占60.8%．伴有结外侵犯者占29.5%，常见部位为脾（14.4%）、肺（5.8%）、骨（5.0%）．Ⅰ/Ⅱ期与Ⅲ/Ⅳ期在性别、病理类型、首发症状、起病部位及一线治疗总有效率等方面的差异均无统计学意义（P＞0.05），在全身症状、ECOG评分及是否化放疗等方面的差异有统计学意义（P＜0.05）．结论 本组HL发病以中年为主，男性多于女性，病理类型、首发症状、起病部位对临床分期无明显影响，临床分期对一线治疗总有效率无明显影响. |
| 关键词: ［关键词］霍奇金淋巴瘤 临床特点 病理类型 |
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| 基金项目:［基金项目］云南省卫生厅内设研究机构基金资助项目（2009NS027） |
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| The Clinical Diagnosis and Treatment of 143 Cases of Hodgkin's Lymphoma |
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YANG Xiao-yun
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（The First Internal Medicine Department，The Third Affiliated Hospital of Kunming Medical University， Yunnan Institute of Oncology Chemotherapy Research Center，The Tumor Hospital of Yunnan Province， Kunming Yunnan 650118，China）
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| Abstract: |
| ［Abstract］Objective To investigate the clinical characteristics of hodgkin's lymphoma（HL） patients . Method The clinical data of HL patients in our hospital from January 1, 2003 to December 31, 2012 were analyzed retrospectively. The contents of investigation included gender, age, pathological type, first symptom, the incidence locations, clinical stages, extranodal involvement locations, ECOG and treatments．Results A total of 143 cases of HL were included， the M/F ratio was 2.5:1 with a median age of 37 years （11~73years）. The most frequent subtypes of HL were mixed cellular （34.3%） and nodular sclerosis（28.0%）. The nodal lymphomas accounted for 97.2%， while the extranodal lymphomas occupied 2.1%. The nodal lymphomas with extranodal invasion accounted for 29.5%，and the common locations were spleen（14.4%），lung（5.8%）and bone（5.0%）. The most clinical stage of all patients was stage Ⅰ/Ⅱ（60.8%），The differences were no significant in gender, pathological type，first symptom，the incidence locations and the effective rate of the first-line treatment（P＞0.05），while were statistically significant in B symptoms，ECOG and treatments between Ⅰ/Ⅱgroups and Ⅲ/Ⅳ groups（P＜0.05）. Conclusions In this group，the incidence of HL patients were mainly found in middle-aged people，males were lager than females.The pathological type，first symptom and the incidence locations had no obvious effect on clinical stage. The clinical stage had no obvious influence on the effective rate of the first-line treatment. |
| Key words: ［Key words］Hodgkin's lymphoma Clinical features Pathologic type |