| 摘要: |
| ［摘要］目的 研究AT1R A1166C、AGT M235T多态性及血生化指标与云南彝族男性原发性高血压（EH）的相关性．方法 通过现场问卷调查和体格检查获取云南省晋宁县92例彝族EH患者和70例彝族健康男性的个人基本资料及血生化指标，采用PCR-RFLP技术检测AT1R A1166C、AGT M235T多态性．结果 （l） 彝族男性EH患者，AT1R 1166C等位基因频率（0.038）和AGT 235T等位基因频率（0.772）与对照组相比差异无统计学意义（P＞0.05），两位点基因型频率与对照组相比亦无差异无统计学意义（P＞0.05）；（2） EH组TC、LDL-C、TG水平显著高于对照组（P＜0.05）．结论 AT1R A1166C、AGT M235T多态性与云南彝族男性EH的发生不相关．高LDL-C、TG、TC水平与云南彝族男性EH的发生可能有关． |
| 关键词: ［关键词］原发性高血压 遗传多态性 血生化指标 彝族男性 |
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| 基金项目:［基金项目］云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（2014FZ004）；云南省教育厅科学研究基金资助项目（2014C038Y） |
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| The Correlation of Polymorphisms of AT1R A1166C and AGT M235T Genes and Blood Biochemical Indicators with Essential Hypertension in the Male of Yi Nationality in Yunnan Province |
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LUO Lan
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（Dept. of Cell Biology and Medical Genetics，School of Basic Medicine，Kunming Medical University， Kunming Yunnan 650500，China）
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| Abstract: |
| ［Abstract］Objective To investigate the correlation of the polymorphisms of angiotensin Ⅱ type 1 receptor （AT1R） gene A1166C and angiotensinogen（AGT）gene M235T and blood biochemical indicators with essential hypertension（EH）in the male of Yi nationality in Yunnan province. Methods 92 hypertensive and 70 normotensive of Yi people were recruited in Yunnan province. Their basic information and blood biochemical indicators were obtained by questionnaire and standardized physical examination. The genes polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）technique. Results（1）For the male EH patients of Yi nationality， 1166C and 235T allele frequencies were 0.038 and 0.772. No significant differences in allele frequency or genotype frequency were observed between the two groups（P > 0.05）. （2）The levels of TC， LDL-C and TG in EH were significantly higher than those in controls（P < 0.05）. Conclusion The AT1R A1166C and AGT M235T polymorphisms were not related to the pathogenesis of EH in the male of Yi people. However， the high levels of TC， TG and LDL-C might be the risk factors of EH. |
| Key words: ［Key words］Essential hypertension Genetic polymorphism Blood biochemical indicator Male of Yi Nationality |