| 摘要: |
| ［摘要］目的 探讨血小板分布宽度和血小板平均体积在云南地区汉族慢性阻塞性肺疾病合并肺动脉高压患者诊断及长期预后判断中的意义．方法 连续收集2012年1月至2013年12月于云南省曲靖市第二人民医院因COPD入院的患者498例，其中COPD合并肺动脉高压216例．入院后记录基本临床资料、血气分析及心脏超声结果，并测定血小板分布宽度，血小板平均体积和NT-proBNP水平．所有资料均使用JMP 9.0和SPSS 18.0统计软件进行统计学分析．结果 COPD合并肺动脉高压组心病组PDW水平［（17.9±1.9% vs. 16.9±2.3%，P＝0.008）］，MPV水平［（13.9±1.5）fLvs （12.4±2.1）fL，P＝0.002］，NT-proBNP水平［（1521.4±925.7）pg/mL vs.（691.9±364.5）pg/mL，P＜0.001］均显著高于COPD无肺动脉高压组．随访12个月时，出现死亡或再次入院等终点事件患者的PDW水平［（19.1±1.8%）vs （17.6±1.4%），P＜0.001］和MPV水平［（14.5±1.5）fL vs（13.7±1.4）fL，P＝0.002］明显高于无终点事件患者．12个月的Kaplan-Meier生存分析显示，PDW和MPV水平较高组患者在12个月时再次入院和死亡等终点事件发生率显著较高（P＝0.018和P＝0.016）．结论 该研究表明PDW和MPV测定对于判断COPD合并肺动脉高压的病情及预后具有比较重要的意义． |
| 关键词: ［关键词］慢性阻塞性肺疾病 肺动脉高压 血小板分布宽度 血小板平均体积 |
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| Significance of Platelet Distribution Width and Mean Platelet Volume in the Prognosis of Chronic Obstructive Pulmonary Disease Combined with Pulmonary Artery Hypertension |
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WANG Zheng-quan
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（Dept. of Cardiology，Second People’s Hospital of Qujing City，Qujing Yunnan 655000，China）
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| Abstract: |
| ［Abstract］Objectives The goal of this study was to analyze the clinical significance of platelet distribution width（PDW）and mean platelet volume（MPV）levels in the prognosis of chronic obstructive pulmonary disease （COPD）combined with pulmonary artery hypertension（PAH）. Methods In a retrospective study， we identified 498 patients with COPD from January 2012 to December 2013 in the second people's hospital of Qujing， 216 of them combined with PAH. We recorded the clinical data， results of blood gas analysis and echocardiography and measured the levels of PDW，MPV and NT-proBNP after admission. The results were statistically analyzed by the statistical package for social sciences（SPSS version 18.0） and software SAS JMP 9.0. Results The levels of PDW［（17.9±1.9%）vs（16.9±2.3）%，P＝0.008］， MPV ［（13.9±1.5）fL vs（12.4±2.1）fL，P＝0.002］and NT-proBNP［（1521.4±925.7）pg/mL vs（691.9±364.5）pg/mL，P＜0.001］in COPD with PAH group were significantly higher than those in COPD without PAH group. At follow up of 12 months， patients with readmission or death had higher values of PDW［（19.1±1.8）% vs（17.6±1.4）%，P＜0.001］and MPV ［（14.5±1.5）fL vs（13.7±1.4）fL，P＝0.002］. Kaplan-Meier survival analysis showed that the rate of readmission and death after 12 months was significantly higher in patients with higher values of PDW（P＝0.018） and MPV （P＝0.016）. Conclusions The detection of PDW and MPV has great signification for the prediction of long-term outcomes in COPD combined with PAH. |
| Key words: ［Key words］Chronic obstructive pulmonary disease Pulmonary heart disease NT-proBNP |