| 摘要: |
| ［摘要］目的 观察阿扎司琼预防月经期女性患者腹腔镜胆囊切除术后恶心呕吐（PONV）的效果．方法 选择ASAⅠ～Ⅱ级择期全麻下行腹腔镜胆囊切除术的月经期女性患者40例，采用随机数字表法，将患者随机分为对照组和阿扎司琼组，每组20例．2组患者均采用常规的麻醉诱导和维持．手术结束前30 min阿扎司琼组静脉注射阿扎司琼10 mg，对照组予等量生理盐水50 mL．观察术后48 h内2组患者PONV的发生率及严重程度． 结果 对照组和阿扎司琼组患者术后48 h内PONV的总发生率分别为90%和35%，阿扎司琼组48 h PONV总发生率明显降低（P＜0.01）；阿扎司琼组，术后恶心呕吐Ⅳ级的发生率也低于对照组（P＜0.05）．结论 阿扎司琼可以减少月经期女性患者行腹腔镜胆囊切除术后恶心呕吐的发生率及降低其严重程度． |
| 关键词: ［关键词］阿扎司琼 术后恶心呕吐 女性 月经期 腹腔镜胆囊切除术 |
| DOI： |
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| 基金项目:［基金项目］云南省卫生系统学科带头人基金资助项目（D-201213） |
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| Azasetron for Prophylaxis of Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy in Female Patients at Menstrual Phase |
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QU Qi-cai
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（Dept. of Anesthesiology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China）
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| Abstract: |
| ［Abstract］Objective To investigate the preventive effects of azasetron against postoperative nausea and vomiting（PONV）after laparoscopic cholecystectomy in female patients at menstrual phase. Methods Forty ASA Ⅰ or Ⅱ female patients at menstrual phase were randomly divided into azasetron group（n＝20）and control group （n＝20）. Induction and maintenance of anesthesia was routine. Azasetron 10mg or normal saline 50 ml was given at 30 min before the end of surgery. The incidence and intensity of PONV was recorded during 48 hours after surgery. Results Compare to the control group, the incidence of PONV was lower at 48 hour after surgery in azasetron group （35% vs 90%，P < 0.01），and the incidence of PONV in Ⅳ level was also lower in azasetron group（P < 0.05）. Conclusion Azasetron can decrease the incidence and intensity of PONV after laparoscopic cholecystectomy during menstrual phase. |
| Key words: ［Key words］Azasetron Postoperative nausea and vomiting Female Menstruation Laparoscopic cholecystectomy |