| 摘要: |
| ［摘要］ 目的 观察夫西地酸乳膏联合卤米松乳膏治疗寻常型银屑病的疗效及安全性．方法 选取54例寻常型银屑病患者作为研究对象，随机分为观察组和对照组．对照组患者26例，外敷卤米松乳膏进行治疗；观察组患者28例，给予卤米松乳膏联合夫西地酸乳膏进行治疗；以银屑病皮损面积和严重程度评分法（psoriasis area and severity index，PASI）评价2种治疗方案的临床疗效并记录不良反应情况．另选取同期健康体检者34例为健康组，比较银屑病患者与健康体检者病原菌感染情况．结果 寻常银屑病患者病原菌感染率为72.22%，其中观察组感染率为75.00%，对照组感染率为69.23%，均显著高于健康组38.24%，差异具有统计学意义（P＜0.05）；治疗后观察组转阴率为95.24%，对照组转阴率为72.22%，2组患者转阴率比较差异具有统计学意义（P＜0.05）；治疗后观察组患者PASI评分及VAS评分均显著低于对照组，差异具有统计学意义（P＜0.05）；观察组治疗总有效率为71.43%，对照组患者治疗总有效率为34.62%，2组比较差异具有统计学意义（P＜0.05）；2组患者治疗过程中不良反应发生率差异无统计学意义（P＞0.05）．结论 病原菌感染与寻常型银屑病的发生密切相关，夫西地酸乳膏联合卤米松乳膏治疗寻常型银屑病的疗效确切，安全性高，值得临床推广应用． |
| 关键词: ［关键词］ 寻常型银屑病 卤米松乳膏 夫西地酸乳膏 感染 |
| DOI： |
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| 基金项目:［基金项目］内蒙古自治区自然科学基金资助项目（2010MS1003）；四川省遂宁市科研基金资助项目（2013-23） |
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| The Efficacy and Safety of Fusidic Acid Cream Combined with Halometasone Cream in the Treatment of Psoriasis Vulgaris |
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WAN Yan1,2
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1.（1）Dept. of Dermatology，Central Hospital of Suining City，Sichuan Province，Suining Sichuan 629000;2） Clinical Medicine Department，Inner Mongolia Medical College，Hohhot Inner Mongolia 010010，China）
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| Abstract: |
| ［Abstract］Objective To observe the efficacy and safety of fusidic acid cream and halometasone cream in the treatment of psoriasis vulgaris. Methods Fifty-four patients with psoriasis vulgaris were enrolled in this study and were divided into observation group and control group. 26 patients in observation group were treated with halometasone cream, 28 patients in control group were treated with fusidic acid cream combined with halometasone cream. The psoriasis area and severity index（PASI）and abverse events of treatment were recorded. At the same time，34 normal people taking physical examination were selected as health group，the infections of pathogenic microorganism were compared between psoriasis vulgaris patients and normal people. Results The pathogenic infection rate of patients with psoriasis vulgaris was 72.22%, the infection rate was 75.00% in observation group and 69.23% in control group. The infection rate in health group was 38.24%，the difference in the pathogenic infection rate was statistically significant between paitents with psoriasis vulgaris and normal people（P＜0.05）. After treatment, the rate of negative infections was 95.24% in observation group and 72.22% in control group, there was significant difference between two groups（P＜0.05）. The PASI scores and VAS scores of observation group were significantly lower than those of control group（P＜0.05）. The total effective rate of treatment was 71.43% in observation group and 34.62% in control group，the difference was statistically significant（P＜0.05）. There was no significant difference in rate of adverse events between observation group and control group（P＞0.05）. Conclusion The pathogenic infection is closely correlated with psoriasis vulgaris，fusidic acid cream combined with halometasone cream has good efficacy and safety in treatment of psoriasis vulgaris and worth of popularization and application. |
| Key words: ［Key words］Psoriasis vulgaris Halometasone cream Fusidic acid cream Pathogenic infection |