| 摘要: |
| ［摘要］糖尿病是当前威胁人类健康最主要的非传染性疾病之一．研究发现：趋化因子不仅参与糖尿病的发病，而且与糖尿病并发症的发生发展也密切相关．C-C亚族趋化因子目前已成为炎症性疾病发病机制的研究热点之一．调节激活正常T细胞表达和分泌的细胞因子（regulate upon activation normal T cell expressed and secreted， RANTES）属于C-C亚族趋化因子的成员．就RANTES及其受体CCR5（CC-chemokine receptor）与糖尿病的关系作一综述． |
| 关键词: ［关键词］RANTES CCR5 基因多态性 糖尿病 |
| DOI： |
| 分类号: |
| 基金项目:［基金项目］国家自然科学基金资助项目（81160104） |
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| Correlation Research of RANTES and Its Receptor CCR5 with Diabetes |
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CHEN Min
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（The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China）
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| Abstract: |
| ［Abstract］Diabetes is one of noncommunicable diseases which is the main current threat to human health. Study founds that chemokines are not only involved in the incidence of diabetes but also related to the development of diabetic complications closely. C - C subtribe chemokine has become a hot of researche in the pathogenesis of inflammatory diseases. RANTES is a type of cytokines which is the member of cysteine-cysteune chemokines. We will review the relationships between RANTES and CCR5 with diabetes. |
| Key words: ［Key words］RANTES CCR5 Gene polymorphism Diabetes |