| 摘要: |
| ［摘要］目的 探讨叉头框C2（FOXC2）基因3’非翻译区C-1702T多态性与2型糖尿病的相关性．方法 选择云南省汉族人280例，其中2型糖尿病患者159例，无糖尿病家族史的健康对照121例．应用半巢式PCR检测FOXC2基因3’非翻译区C-1702T多态性．结果 在2型糖尿病组和对照组中，FOXC2基因C-1702T的基因型和等位基因频率无统计学意义（P＞0.05），并与性别无关（P＞0.05）．在2型糖尿病患者中与FOXC2基因1702杂合子和突变型（C/T和T/T）相比，FOXC2基因1702C/C野生型者，其血清胆固醇的水平明显升高（P＜0.05）．结论 FOXC2基因C-1702T基因多态性与性别及2型糖尿病没有相关性．2型糖尿病患者FOXC2基因3’非翻译区C-1702T多态性与血清总胆固醇相关． |
| 关键词: ［关键词］FOXC2 2型糖尿病 多态性 |
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| The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol |
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NIAN Xin
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| Abstract: |
| ［Abstract］Objective To investigate the association between the forkhead transcription factor C2（FOXC2）C-1702T transition in the putative promoter region and type 2 diabetes．Methods 280 han people in Yunnan province were selected as subjects. A case-control study was performed in 159 type 2 diabetic patients and 121 control subjects．The FOXC2 gene C-1702T polymorphism was detected by heminested PCR．Results FOXC2 C-1702T allele and genotype distribution did not differ between patients with type 2 diabetes and control subjects（P＞0.05）， and had no association with gender. The C/C genotype was associated with higher level of cholesterol（P＜0.05）among type 2 diabetic patients．Conclusions FOXC2 C-1702T is not associated with gender and type 2 diabetes. FOXC2 C-1702T is associated with serum cholesterol. |
| Key words: ［Key words］Forkhead transcription factor Type 2 diabetes Polymorphism |
